Course Syllabus

In order to replicate and propagate, viruses must contend with an onslaught of immune responses at both the intracellular and organismal levels. Evolutionarily, this leads to an arms race between viruses and the immune system, as each evolves mechanisms to overcome the other. This course provides an introduction to several viruses that cause human disease and the immune responses that they evade or succumb to. The course is organized in two sections: first, introduction of the immune responses most relevant for viral infection (including antibodies, T cells, natural killer cells, and intracellular nucleic acid sensors); and second, discussion of viruses famous for their impact on society and human health (including HIV, Ebola, and herpesviruses, among others). Each virus is explored in the context of its replication, mechanisms of transmission, and interaction with the immune system. We conclude with presentations led by graduate-credit students, which may extend to viruses beyond those previously examined in the course and to specialized topics, such as applications of viruses in biotechnology and therapeutics. Graduate students also participate in discussions of primary scientific literature related to lecture topics throughout the course. Because molecular virology, immunology, and interactive learning are core components of the course, students should come prepared with confident mastery of introductory cell and molecular biology, and willingness to participate in critical thinking activities that involve discussing their ideas with their peers.